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方葛敏


方葛敏
职 称:  特聘教授
职 务:  课题组长(PI)
E-Mail:


fgmsxy@gmail.com

学科类别:化学生物学
学习经历:

  

2006年本科毕业于安徽师范大学化学专业

2009年硕士毕业于中国科学技术大学

2012年获得清华大学有机化学专业博士学位。


工作经历:

20127月至201310月,以助理研究员身份在中科院合肥物质研究院强磁场科学中心工作

2013年底至20178月以洪堡学者身份在德国洪堡大学从事科学研究;

20179月到安徽大学工作。


主要研究领域:

   生物大分子的合成、功能与应用

承担科研项目情况:

  

曾获得2011年度教育部博士生学术新人奖、2016年洪堡学者,2018年入选安徽省“百人计划”


代表论著:

1. Gemin Fang, Seitz Oliver. 2017. Bivalent display of dicysteine on Peptide nucleic acids for homogenous DNA/RNA detection through in situ fluorescence labelling. ChemBioChem, 18: 189-194.

2. Yichao Huang, Gemin Fang, Lei Liu. 2016. Chemical synthesis of proteins using hydrazide intermediates. Natl. Sci. Rev. 3: 107-116.

3. Jiaxin Wang#, Gemin Fang#, Yao He, Daliang Qu, Mu Yu, Zhangyong Hong, Lei Liu. 2015. Peptide o-Aminoanilides as Crypto-Thioesters for Protein Chemical Synthesis. Angew. Chem.Int. Ed., 54: 2194-2198.

4. Shuai Gao, Ye Guo, Haiyan Li, Gemin Fang. 2014. Chemical synthesis and application ofstapled peptides. Prog. Chem., 26: 100-109.

5. Yanyan Si, Ye Guo, Haiyan Li, Haoyuan Sun, Gemin Fang. 2014. Recent advances in chemical synthesis of backbone cyclized peptides. Chin. J. Org. Chem., 34: 450-460.

6. Yitong Li, Jun Liang, Jiabin Li, Gemin Fang, Yichao Huang, Lei Liu. 2014. New semi-synthesis of ubiquitin C-terminal conjugate with 7-amino-4-methylcomarin. J. Pept. Sci., 20: 102-107.

7. Jun Liang, Gemin Fang, Xiuliang Huang, Ziqing Mei, Juan Li, Changlin Tian, Lei Liu. 2013. Chemical synthesis of Ub-AMC via ligation of peptide hydrazides. Sci. China Chem., 56: 1301-1306.

8. Qiaoqiao He, Gemin Fang, Lei Liu. 2013. Design of thiol-containing amino acids for native chemical ligation at non-Cys sites. Chin. Chem. Lett., 24: 265-269.

9. Gemin Fang, Jiaxin Wang, Lei Liu. 2012. Convergent chemical synthesis of proteins by ligation of peptide hydrazides. Angew. Chem. Int. Ed., 51: 10347-10350.

10. Gemin Fang, Yiming Li, Fei Shen,Yichao Huang, Jiabin Li, Yun Lin, Hongkui Cui, Lei Liu. 2011. Protein chemical synthesis by ligation of peptide hydrazides. Angew. Chem. Int. Ed., 50: 7645-7649.

11. Gemin Fang, Hongkui Cui, Jisheng Zheng, Lei Liu. 2010. Chemoselective ligation of peptide phenyl ester with N-terminal cysteines. ChemBioChem, 11: 1061-1065.

12. Jishen Zheng, Hongkui Cui, Gemin Fang, Weixian Xi, Lei Liu. 2010. Chemical protein synthesis by kinetically controlled ligation of peptide O-esters. ChemBioChem, 11: 511-515.

13. Juan Li, Jishen Zheng, Fei Shen, Gemin Fang, Qingxiang Guo, Lei Liu. 2007. Chemical synthesis of proteins. Prog. Chem. 19: 1866-1882.

15. Lei Liu, Gemin Fang, Yiming Li, Fei Shen, Yichao Huang, Jiabin Li, Yun Lin, Hongkui Cui. 中国专利号 201110062686A method for chemical synthesis of protein.




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