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杨兴元
职 称:  教授
职 务:  课题组长(PI)
E-Mail:

stanleyxingyuan(at)aliyun(dot)com


学科类别: 生物化学与分子生物学
学习经历:

    1992-1996      山西农业大学(生物技术)     理学学士

    1997-2000      山西农业大学(生物技术)     理学硕士

    2000-2003      中国农业大学(基因工程)     理学博士

工作经历:


  2003-2006       中国农业大学                 讲师

   2006-2009       University of Kentucky       postdoctoral

   2009-2011       University of Kentucky       Research Scientist

   2011-2014       Mayo Clinic                  Research Scientist

   2014-至今       安徽大学                     教授


主要研究领域:

    生物医学(生化与分子生物学) 代谢与癌症

承担科研项目情况:

  1. NIH R01 Grant(1R01DK89178). Inhibition of ATGL-mediated lipolysis by G0S2.  $125,000.00(7/2010-6/2015)

  2. ADA Junior Faculty Award (1-10-JF-30).   Regulation of adipose lipolysis by a novel inhibitor.   $120,000 (1/2010-

      12/2012)

  3. Children’s Miracle Network Research Grant. Roles of lipolytic regulators in the development of hepatic steatosis. 

      $20,000(10/2009-9/2011)

  4. NIH COBRE Pilot Grant.  The Inhibitory Role of Integrin α5 in adipocyte differentiation $10,000 (9/2007-8/2009)

  5. NIH R56 Grant. The roles of integrin receptors in adipocyte differentiation .  $50,000 (8/2008-7/2009)

  6. AHA. Ihibition of ATGL-Mediated fat mobilization by G0S2 in mouse liver 08POST2050228. $90,000 (6/2008-

      7/2010) 

代表论著:

 24. Jiajun Cui, Yutao Yang, Jiajun Cui, Quan Huang,Zejun Lu, Jie Chen,Ting Sun, Ruiqin Wu, Yansong Sun, Hongbin Song, Xionghui Wei, Xingyuan Yang* and Chuanfu Zhang*.   MiR-873 regulates ERα transcriptional activity and tamoxifen resistance via targeting CDK3 in breast cancer cells. Oncogene. 2015 Jul 23;34(30):4018. IF=8.459.

23.Bradlee L. Heckmann,Xiaodong Zhang, Xitao Xie,Saarinen A, Xin Lu, Xingyuan Yang and Jun Liu. Defective adipose lipolysis and altered global energymetabolism in mice with adipose overexpression of the lipolytic inhibitor G0/G1Switch Gene 2.  The Journal of BiologicalChemistry.2014 Jan 24;289(4):1905-16.

22. Xingyuan Yang, Bradlee L. Heckmann, Xiaodong Zhang, and Jun Liu. Regulation of ATGL-mediated adipocyte lipolysis by lipid droplet coat proteins.Molecular Endocrinology. 2013.27(1):116-26IF=4.746

  21. Bradlee L. Heckmann,Xingyuan Yang, Xiaodong Zhang, and Jun Liu. The autophagy inhibitor 3-methyladenine (3-MA) potently stimulates PKA-dependent lipolysis in adipocytes.British Journal of Pharmacology. 2013.168(1):163-71.IF=5.06

  20.Xingyuan Yang, Bradlee L. Heckmann, Xiaodong Zhang, Xitao Xie and Jun Liu. Hepatic Overexpression of the lipolytic inhibitor G0S2 impedes fatty acid oxidation and promotes hepatic steatosis. (In Review)Hepatology. 2013.IF=12.003

  19.Xingyuan Yang, Xiaodong Zhang, Bradlee Heckmann, Xin Lu and Jun Liu. Relative Contribution of Adipose Triglyceride Lipase and Hormone-sensitive Lipase to TNF-alpha-induced Lipolysis in Adipocytes.The Journal of Biological Chemistry.2011.286(11):40477-40485.IF=4.651

  18. Stephan Wueest,Xingyuan Yang,Jun liu,Eugen J. Schoenle and Daniel Konrad. Inverse regulation of basal lipolysis in different intra-abdominal fat depots in insulin-resistant mice.Am J Physiol Endocrinol Metab2012.302: E153–E160.IF=4.514

 17.Xingyuan Yang, Xin Lu, Marc Lombès, Geun Bae Rha, Young-In Chi, Theresa M. Guerin, Eric J. Smart and Jun Liu. The G0/G1 Switch Gene 2 Regulates Adipose Lipolysis through Association with Adipose Triglyceride Lipase.Cell Metabolism.2010.11(3):194-205.IF=17.551

 16.Xingyuan Yang, Xin, Lu, and Jun Liu. Identification of a novel splicing isoform of murine CGI-58.FEBS Letters.2010.584(4): 903-910.IF=3.582

  15. Xin Lu♯,Xingyuan Yang♯ and Jun Liu. Differential control of ATGL-mediated lipid droplet degradation by CGI-58 and G0S2.Cell Cycle. 2010. 9(14): 2719-2725.(Co-first author)IF=5.243

  14. Lei Zhang,Xingyuan Yang,Xiaorong An, Yongfu Chen.The Construct of Myostatin Gene Targeted Recipient Myoblast Cell.China Biotechnology. 2009.7:27-31.

  13. Lei Zhang,Xingyuan Yang,Xiaorong An, Yongfu Chen. The Construct of Promoter-trap and PolyA-trap Gene Targetting Vector and the Preparation of Recipient Myoblast Cell .Journal of Jilin University(Science Edition).2009.6:230-235.

  12.Limei Chen, Min Li, Qiuyan Li,Xingyuan Yang, Xiaorong An and Yongfu Chen. Characterization of the bovine immunoglobulin lambda light chain constant IGLC genes.Veterinary Immunology and Immunopathology2008.124(3): 284-294.IF=2.17

  11.Lei Zhang,Xingyuan Yang, Xiaorong An and Yongfu Chen. Myostatin gene targeting in cultured China Han ovine myoblast cells.Animal.2007. 10(1):1401-1408.IF=1.648

  10. Huazhong Liu,Xingyuan Yang, Qing Li , Xiaorong An, Yongfu Chen, Jieping Zhong, Kun Li. Expression of bovine basic fibroblast growth factor gene in Escherichia coli and bioactivity of the expressed product.Veterinary Science in China. 2007. (10):73-77

  9. Huazhong Liu, Qing Li,Xingyuan Yang, Ling Liu, Lei, Liu, Xiaorong An and Yongfu Chen. Expression of Basic Fibroblast Growth Factor Results in the Decrease of Myostatin mRNA in Murine C2C12 Myoblasts.Acta Biochimica et Biophysica Sinica2006.38(10): 697-703.IF=1.807

  8. Min Li, Limei Chen, Aixing Lin,Xingyuan Yang, Xiaorong An, Yongfu Chen. Cloning and Characterization of Two JH and CμIg Genes in Bovine Germline Gene. Prog.Biochem. Biophy. 2005.32(9):857-864.

  7. Rong Du, Yongfu Chen, Xiaorong An,Xingyuan Yang, Yi Ma, Lei Zhang, Xiaoli Yuan, Limei Chen and Jian Qin. Cloning and sequence analysis of myostatin promoter in sheep.DNA Sequence. 2005.16(6):412-417.IF=0.75

 6. Xingyuan Yang, Shuhong Yang, Jian Hou, Yongfu Chen. Cloning and Expression of Pr Domain of Mutation Myostatin and Its Biochemical Activity.Journal of Agricultural Biotechnology. 2004.12 : 56-60.

  5. Shuhong Yang,Xingyuan Yang, Jian Hou, Yongfu Chen. Cloning and Expression of the Single- chain Fv Fragment Gene against Bull Sperm sp18.High Technology Letters.2004. 14(8):37-41.

  4.Xingyuan Yang, Shangzhong Xu, Ruliang Yu, Zhongxiao Zhou. The Application of AFLP fingerprint in Breed Discrimination of Simmental,Yanbian, Nanyang Cattle.Journal of Yellow Cattle Science. 2003. 29: 8-11.

  3.XingYuan Yang, Jian Hou, Xiaorong An, Hong Guan, Kemian Gou, Shuhong Yang, Lidong Chen and Yongfu Chen. Molecular Cloning, Expression of mutant of bovine Myostatin and Its Biochemical Activity.Chinese Journal of Biotechnology. 2003.19: 480-483.

  2. Kemian Gou, Xiaorong An, Hong Guan,Xingyuan Yang, Jian Hou, Shien Zhu, Shengming Zeng, Jianhui Tian, Yongfu Chen. Transgenic twin lambs cloned by granulosa cells.Cloning and Stem Cells. 2003.5(1):71-78.IF=2.744

  1. Lidong Chen, Aixing Lin, Yali Zhang,Xingyuan Yang, Xiaorong An. Cloning of the Genomic Fragment of Bovine Alpha (1, 3)-galactosyltransferase Gene and Construction of a New Kind of Promoterless Targeting Vector.High Technology Letter. 2003. 13: 25-29.


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