今天是:2017年12月13日 星期三

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秦曦明
职 称:   教授
职 务:   课题组长(PI)
E-Mail:


 qin(dot)ximing(at)ahu(dot)edu(dot)cn   (Primary) 

 ximing(dot)qin(at)gmail(dot)com (Secondary)

学科类别: 时间生物学/生物化学/细胞生物学
学习经历:

    2004 - 2010       美国Vanderbilt University, 生物科学系            博士

    2001 - 2004       清华大学,   生物科学和技术系                    硕士

    1997 - 2001       山东大学,   生物系                               学士                                           

工作经历:

   2010-2014      Vanderbilt University      postdoctoral

   2014-至今      安徽大学                   教授

     2016年安徽省第五批“百人计划”

 

主要研究领域:

    1、生物钟(昼夜节律)的分子基础

    2、生物钟与睡眠

    3、生物荧光在生物医学中的应用

承担科研项目情况:

国家自然科学基金面上项目 (31571208,2016-2019)  

 安徽大学引进人才启动基金 (2014-2019

代表论著:

17. Qin X, Mori T, Zhang Y, Johnson CH (2015) PER2 Differentially Regulates Clock Phosphorylation versus Transcription by Reciprocal Switching of CK1ε Activity. J Biol Rhythms 30: 206-16. doi: 10.1177/0748730415582127.

16. Xu Y, Weyman PD, Umetani M, Xiong J, Qin X, Xu Q, Iwasaki H, Johnson CH (2013) Circadian Yin-Yang Regulation and Its Manipulation to Globally Reprogram Gene Expression. Curr Biol 23: 2365-74.

15. Villarreal SA, Pattanayek R, Williams DR, Mori T, Qin X, Johnson CH, Egli M, Stewart PL (2013) CryoEM and molecular dynamics of the circadian KaiB-KaiC complex indicates that KaiB monomers interact with KaiC and block ATP binding clefts. J Mol Biol 425:3311-24.

14. Edgar RS, Green EW, Zhao Y, van Ooijen G, Olmedo M, Qin X, Xu Y, Pan M, Valekunja UK, Feeney KA, Maywood ES, Hastings MH, Baliga NS, Merrow M, Millar AJ, Johnson CH, Kyriacou CP, O'Neill JS, Reddy AB (2012) Peroxiredoxins are conserved markers of circadian rhythms. Nature 485:459-64.

13. Egli M, Mori T, Pattanayek R, Xu Y, Qin X, Johnson CH (2012) Dephosphorylation of the core clock protein KaiC in the cyanobacterial KaiABC circadian oscillator proceeds via an ATP synthase mechanism. Biochemistry 51:1547-58.

12. Qin X, Byrne M, Mori T, Zou P, Williams DR, McHaourab H, Johnson CH (2010) Intermolecular associations determine the dynamics of the circadian KaiABC oscillator. Proc Natl Acad Sci USA 107: 14805-14810.

11. Qin X, Byrne M, Xu Y, Mori T, Johnson CH (2010) Coupling of a core post-translational pacemaker to a slave transcription/translation feedback loop in a circadian system. PLoS Biol 8: e1000394.

10. Xu Y, Mori T, Qin X, Yan H, Egli M, Johnson CH (2009) Intramolecular regulation of phosphorylation status of the circadian clock protein KaiC. PLoS One 4: e7509

9. Woelfle MA, Xu Y, Qin X, Johnson CH (2007) Circadian rhythms of superhelical status of DNA in cyanobacteria. Proc Natl Acad Sci USA 104:18819-24.

8. Mori, T, Williams DR, Byrne MO, Qin X, Egli M, Stewart PL, and Johnson CH (2007) Visualizing the Ticking of an in vitro Circadian Clockwork. PLoS Biol 5: e93.

7. He H, Tang Y, Qin X, Xu W, Wang Y, Liu X, Liu X, Xiong S, Li J, Zhang M, Duan M (2005) Construction of a eukaryotic expression plasmid encoding partial S gene fragments of the SARS-CoV and its potential utility as a DNA vaccine. DNA Cell Biol 24: 516-520.

6. Hong-Xuan H, Lei C, Cheng-Min W, Kai Z, Yi T, Xi-Ming Q, Ming-Xing D. (2005) Expression of the recombinant fusion protein CP15-23 of Cryptosporidium parvum and its protective test. J Nanosci Nanotechnol 5: 1292-1296.

5. Zhang QZ, Qin XM, Dong HL, et al. (2005) Efficient protection of H5N1 influenza virus DNA vaccine delivering by electroporation in mammalian and avian system. Prog Biochem Biophys 32: 726-733.

4. He H, Zhao B, Liu L, Zhou K, Qin X, Zhang Q, Li X, Zheng C, Duan M. (2004) The humoral and cellular immune responses in mice induced by DNA vaccine expressing the sporozoite surface protein of Cryptosporidium parvum. DNA Cell Biol 23: 335-339.

3. Qin XM, Duan MX, Deng B, Zhang QZ, et al. (2004) Isolation and identification of a new thymic peptide from calf thymus. Biochemistry (Mosc) 69: 921-925.

2. HE HX, QIN XM, ZHANG QZ, TANG Y, et al. (2004) Cloning of HA Gene of H9N2 Subtype Avian Influenza Virus and Immune Protection Test of Its DNA Vaccine. Prog Biochem Biophys 31: 163-166. (in Chinese)

1. Zhang QZ, Qin XM, Liang L, Duan MX, et al. (2003) Construction and Expression of Avian Influenza Virus HA Gene Eukaryotic Vectors. Prog Biochem Biophys 30: 483-487. (in Chinese)


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